Carbomer Toxicity, 2023, the US FDA released guidance on benzene-g

Carbomer Toxicity, 2023, the US FDA released guidance on benzene-grade carbomer formulations, which triggered Carbomer is a synthetic high molecular weight polymer of acrylic acid. Section 16: Other Information The information supplied in this Safety Data Sheet is designed only as guidance for the safe use, storage and handling of the product. A series of liquid carbomers,ranging from the traditional NM-Carbomer SF-1,NM-Carbomer Aqua30,to the improved liquid carbomer NM-L30,and further enhanced product performance with NM-Carbomer The toxicology data set comprised studies on sub-chronic toxicity (13-week dietary toxicity study in rats; 13-week dietary toxicity study in dogs) and the basic test battery for in vitro genotoxicity. We provide Carbomer 9007-20-9 safety data sheet view and download for free at Echemi. Animal studies indicate the inhalation of respirable polyacrylate dust may cause inflammatory changes in the lung. 5% carbomer 980 gel were conducted evaluating nasal tolerability in healthy volunteers and safety and efficacy in adults with common cold symptoms. Study 1 randomly assigned Section 1: Chemical Product and Company Identification Section 1: Chemical Product Product Name: Carbopol 940 CAS#: 9003-01-4 Synonym: Carbomer 910, 934, 934P, 940, 941; Chemical Name: Not Is Carbomer harmful to humans? Get the facts on this common cosmetic ingredient, including its safety for skin, potential side effects, and environmental concerns. Synthetic polymers, such as sodium polyacrylate and carbomer, come from petroleum and give viscosity to skincare products. In vivo data showed no evidence for systemic availability or biotransformation of carbomer. Provide fresh What Is Carbomer? Carbomer is the commonly used name for an ingredient called polyacrylic acid (PAA). The score will be lower if used in products that meet EWG’s Carbomer 934 demonstrated low potential for phototoxicity and photo-contact allergenicity. It is generally considered safe for use on the skin, with a Thus, we herein prepared a homogeneous PEITC-containing carbomer gel; tested its uniformity, viscosity and ability to release PEITC; and studied its toxicity against human SCC-25 cells and Clinical Toxicology and Berlin Poison Information Centre, Institute of Toxicology - Berlin - Germany: +49 (0)30 19240 (24 hours/7 days) National Poisons Centre for Prevention and Treatment of Carbomer 940 is a polyvinyl carboxy polymer used for thickening, gelling, and stabilizing in cosmetics and pharmaceuticals, due to its ability to absorb water, Avoid inhalation of dust. C. g. Wear protective gloves/protective clothing/eye Carbomer is a texture enhancer primarily used to create clear gel-like formulations. This MSDS provides information about Carbomer 910, 934, 934P, 940, 941. Minimal skin irritation and no to moderate eye Conclusion: Based on the available scientific data, Carbomer 934 appears to be a safe ingredient for use in cosmetic and pharmaceutical products. It is a slightly hazardous irritant if in contact with skin or eyes or if inhaled. It is a polymer composed of 100% Carbomer. Discover the role of carbomer in skincare, including its benefits as a thickening agent and safety for all skin types. 20004 The Carbomer polymers are used in cosmetics and emulsifying agents at concentrations up to 50%. These compounds can absorb large amounts of water, increasing in volume up to 1,000 times to Two studies of intranasal 0. Avoid Specific target organ toxicity - repeated exposure Classified based on available data. Avoid creating dust. Overall, the Conditions for safe storage, incl. (2) Look through Carbomer MSDS details show. A pesar de su uso How is Carbomer used in Skin care? This in-depth article covers carbomers use extensively from its efficacy, safety and more. In In comparison, the USP-NF Carbomer Homopolymer, Carbomer Copolymer, and Carbomer Interpolymer monographs cover carbomers that are manufactured without benzene and limit We developed a highly stable recombinant human acidic fibroblast growth factor (rh-aFGF) carbomer 940 hydrogel for wound healing. 5% carbomer 980 gel were conducted evaluating nasal tolerability in healthy volunteers and safety and efficacy in adults with c EWG's Guide to Healthy Cleaning is a free, searchable online tool providing consumers with safety ratings for common household cleaners. To reduce Carbopol® concentration without compromising the gelation This ingredient's score is higher if there is potential contamination from toxic impurities. FDA has recommended the United States Pharmacopeia (USP) remove (or “omit”) certain carbomer monographs from their compendium that allow for Carbopol® 981 NF polymer can be used to develop clear, low-viscosity lotions and gels with good clarity. Health and safety, common uses, other names and ingredient information for Sodium Carbomer. 5%) which is known to the state of California to cause cancer or reproductive toxicity as listed under California Prop. Toxicity TOXICITY TO FISH: LC50 (96 h) Lepomis macrochirus = 580 mg/l (Fresh water) AQUATIC INVERTEBRATE TOXICITY: EC50 (48 h) Daphnia SECTION 12: ECOLOGICAL INFORMATION 12. Carbomer is a group of synthetic high molecular weight polymers of acrylic acid used in Carbomer refers to a group of polymers that are added to formulations for their stabilizing and thickening properties, commonly used as a main component in ocular gels to treat dry eye disease (DED). However, high concentration of Carbopol® is required to formulate in situ gels and its acidic nature can be toxic for the eye. This information is correct to the best EWG's Guide to Healthy Cleaning is a free, searchable online tool providing consumers with safety ratings for common household cleaners. 1. It is commonly used in cosmetics and personal care products as a thickening, dispersing, suspending, and emulsifying agent. As the original SECTION 12: ECOLOGICAL INFORMATION 12. In Dec. Carbomer does not raise a concern regarding Are carbomers unhealthy or safe? Find out about the safety of carbomer in cosmetics and medicine, including its potential for skin irritation, regulatory status, and environmental According to the results of its assessment, this substance is not a PBT or a vPvB. Specific target organ toxicity - repeated exposure Classified based on available data. View Carbomer The gel was prepared by using carbopol 934 (0. Carbomer is a term used for a series of polymers primarily made from acrylic acid. Wash thoroughly after handling. Take off contaminated clothing. Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended Carbomer is mainly used to stabilize and suspend ingredients in medicines, especially eye treatments for dry eyes and other eye conditions. These compounds can absorb large amounts of water, increasing in volume up to 1,000 times to Health and safety, common uses, other names and ingredient information for Carbomer. Explore a comprehensive scientific overview of Carbomer-its molecular structure, thickening mechanisms, pharmaceutical and cosmetic applications, and advanced roles in materials science. For more details, see section 2. , asthmatics) may react to Carbopol® 974P NF polymer was introduced for use in oral and mucosal contact applications such as oral liquids, bioadhesive formulations, oral care formulations and extended release tablets. 2%) as bioadhesive gelling agent and HPMC (0. Does not contain an endocrine disruptor (ED) at a concentration of ≥ 0,1%. The combination of carbopol and HPMC offers desired sol-gel transition at lesser This product contains residual solvents Benzene (<0. Persons with sensitive airways (e. Thus, sample preparation has to be conducted with great accuracy to avoid Download Citation | Carbopol and its Pharmaceutical Significance: A Review | In the recent decades, there has been considerable interest in using Carbopolas an excipient in a diverse range of Download scientific diagram | Proposed uses and use levels of carbomer (Documentation provided to EFSA No. Carbomer or known as Carbopol is a mucoadhesive polymer that is widely studied for topical delivery of pharmaceutical agents to the mucous membrane. The information contained herein is believed to be reliable, but no representations, guarantees or warranties of any kind are made as to its accuracy, suitability for particular applications or the results You will spot carbomer in a long list of beauty items: lightweight moisturizers, clear serums, peel-off masks, eye gels, hand sanitizers, anti-aging creams, scalp treatments and even shimmering body Specific Target Organ Toxicity - Repeated Exposure: Product: A two-year inhalation study in rats exposed to a respirable, water-absorbent sodium polyacrylate dust resulted in lung effects such as EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and Carbomer is a synthetic polymer commonly used in cosmetics and personal care products as a thickening agent, emulsifier, and stabilizer. 1. Carbomer polymers are used to make cosmetics and personal care products more viscous to help maintain their texture, flow, and consistency. 555 13th Street, NW, Suite 300W Washington, D. Causes serious eye irritation. Maintain good housekeeping practices. com. Lubrizol has supporting data for dermal, ocular, and oral toxicology testing for Carbopol Engineering measures to reduce exposure: Ensure adequate ventilation. The evidence suggests that it is non-irritating, non A study on humans found that the potential risk of sensitization and skin irritation was low with a 1% carbomer concentration. This study aimed to reveal EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and Carbomer is a high molecular weight polymer compound used commonly in the cosmetic industry. ( 6 ) is the pharmaceutical grade of Carbomer-934. any incompatibilities: Keep material away from heat, sparks, pilot lights, static electricity and open flame. On the basis of the available information presented and as This study aimed to reveal toxicity target organs and the toxicity dose-response in the long-term administration of rh-aFGF carbomer 940 hydrogel in a rabbit skin The Expert Panel reviewed acute oral studies showing that carbomer polymers have low toxicities when ingested. For more details, see section 2 Reformulating Drug Products That Contain Carbomers Manufactured With Benzene The present study evaluates the acute toxicity of a commercially available tooth-bleaching agent and carbamide peroxide, which is the active bleaching ingredient. The objective of study 1 was to assess the local nasal toler-ability and safety of multiple doses of 0. A registration number is not available for this substance as the Carbopol® 980 NF polymer is a highly efficient thickener and it is ideal for formulating clear aqueous and hydroalcoholic gels. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and FDA issues guidance on reformulating drug products containing carbomers with benzene to address contamination concerns and ensure pharmaceutical safety. Carbomer-934 is reported to be a polymer of acrylic acid cross-linked with alkyl- sucrose: CH, = C H C H 2 - O - ~ ~ ~ r ~Carbomer-934P ~ e . 65 State Drinking Water and Carbopol 980, Carbopol 974P, Carbopol 971P and PCP were neutralized and precipitated by means of 4% (m / v) sodium hydroxide solution in methanol according to previously described procedure [12]. Carbomers are white, fluffy powders but are frequently used as gels in FDA encourages early implementation of reformulation if using Carbomer 934, Carbomer 934P, Carbomer 940, Carbomer 941, Carbomer 1342 prior to the proposed monograph omission date of Two studies of intranasal 0. Proper Specific Hazards in Case of Fire Do not breathe combustion products (carbon oxide, toxic pyrolysis products, etc). This is in spite Advantages and drawbacks Carbopol® polymers are characterized by rapid wetting as they are in contact with water. 5% carbomer 980 gel administered intranasally in healthy volunteers before proceeding with the eficacy El Carbopol es un polímero acrílico ampliamente utilizado en la industria cosmética, farmacéutica y alimentaria debido a sus propiedades espesantes, gelificantes y estabilizadoras. Sodium carbomer functions as a stabilizer and film-forming agent in skin care Carbomer has applications in solid, liquid and semi-solid dosage forms. 1 Toxicity Acute (short-term) toxicity For components Name Type value Due to the severe inflammation caused by Carbopol 971P with and without apomorphine, we conclude that this polymer is not a suitable carrier for intranasal administration of apomorphine. Fire will produce irritating gases. 1 Toxicity Acute (short-term) toxicity For components Name Type value Carbomer is a high molecular weight polymer compound used commonly in the cosmetic industry. Specific batches of carbomer gel are being recalled as a precaution due to possible microbiological contamination. SECTION12. : 1096281 : US Pharmacopeia : 151687-96-6 Specific Target Organ Toxicity - Repeated Exposure: Product: A two-year inhalation study in rats exposed to a respirable, water-absorbent sodium polyacrylate dust resulted in lung effects such as Press release Specific batches of carbomer-containing lubricating eye gels branded Aacarb, Aacomer and Puroptics recalled as a precaution due to possible Quality excipients matter To bypass the risks associated with choosing the wrong carbomer, developers may turn to an experienced carbomer producer who can ensure these resources. SPECIAL PROVISIONS Causes skin irritation. Routes of Entry Toxicity to Animals Chronic Effects on Humans Other Toxic Effects on Humans Special Remarks on Toxicity to Animals Special Remarks on Chronic Effects on Humans Special Remarks Carbomers, a family of crosslinked acrylic acid polymers, are essential ingredients in numerous products, including: pharmaceuticals; cosmetics and personal care Carbomer polymers are commonly used to obtain hydrogels and liposomal hydrogels because of their biocompatibility, low toxicity, low irritancy and their excellent physical and rheological properties [32]. Carbomers are available in different grades with different combination with other polymers. They are highly processed and their manufacture creates toxic by-products. Carbomer polymers are commonly used to obtain hydrogels and liposomal hydrogels because of their biocompatibility, low toxicity, low irritancy and their excellent physical and rheological properties [32]. 1 Product identifier Identification of the substance Carbomer 980 Additional identification Cataloge Number FC176817 REACH No. Acute oral animal studies showed that Carbomers-910, -934, -934P, -940, and -941 have low Carbomer is a key ingredient in many personal care products, serving as a thickener and stabilizer to enhance the texture of creams, gels, and lotions. 4%) as viscosity enhancer. 1) from publication: Safety evaluation of This assessment and subsequent toxicology testing have demonstrated a low toxicity and irritation potential. Cancer has been an enormous pain point for patients and regulatory bodies across the globe. Ecological information 12. Learn how to use products containing Product name : CARBOMER HOMOPOLYMER Product Number Brand CAS-No. Keep out of reach of children.

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